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To determine whether the phosphodiesterase type 5 inhibitor, Sildenafil citrate, affects uteroplacental perfusion. Based on a randomized double-blinded and placebo-controlled trial, forty one pregnant women with documented intrauterine growth retardation at weeks of gestation were evaluated for the effect of a single dose of Sildenafil citrate on uteroplacental circulation as determined by Doppler ultrasound study of the umbilical and middle cerebral arteries. Doppler velocimetry index values reflect decreased placental bed vascular resistance after Sildenafil. Sildenafil citrate can improve fetoplacental perfusion in pregnancies complicated by intrauterine growth restriction. It could be a potential therapeutic strategy to improve uteroplacental blood flow in pregnancies with fetal growth restriction FGR. Excluding fetal anomalies, after prematurity, fetal growth restriction FGR is the second common cause of perinatal morbidity. In a normal pregnancy, the trophoblast produces nitric oxide NO which plays an important role in vasodilatation in the fetoplacental circulation to improve oxygen and nutritional supply to the fetus.

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It's the active ingredient in both branded Viagra and the drug Revatio, which is a lower dose than Viagra and approved to treat pulmonary arterial hypertension. At a lower dose, sildenafil is approved to sildenafil 380 mg price pulmonary arterial hypertension—the higher dose is reserved for treating erectile dysfunction ED. Anawalt explains that there's a chance your insurance might not cover it to treat ED. Still, if your doctor says it's okay for you to use and you end up paying out-of-pocket, you can still get the generic for a lot less than Viagra. That's still far less expensive than one Viagra pill. Teva Pharmaceuticals plans to release its generic of the little blue pill as early as December.

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