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In addition, the chemotrigger zone of the medulla contains dopamine-containing neurones that initiate vomiting in response to noxious and possibly toxic substances. It is thought that there is an abnormality of dopamine receptors or increased release of dopamine in the mesolimbic and mesocortical pathways in schizophrenics.
Authored by Dr. Courtney A. Keith, MD
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Other tissues where significant metabolism of drugs can occur include the intestinal mucosa, the lungs and plasma.
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Some ion channels are linked directly to a receptor, others are activated by G-proteins and drugs that interact with these receptors will affect the functioning of the channels.
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