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Sildenafil, sold under the brand name Viagra, among others, is a medication used to treat erectile dysfunction and pulmonary arterial hypertension. Common side effects include headaches, heartburn, and flushed skin. Sildenafil acts by blocking phosphodiesterase 5 PDE 5, an enzyme that promotes breakdown of cGMP, which regulates blood flow in the penis. Pfizer originally discovered the medication in while looking for a treatment for angina. The primary indication of sildenafil is treatment of erectile dysfunction inability to sustain a satisfactory erection to complete sexual intercourse. Its use is now one of the standard treatments for erectile dysfunction, including for men with diabetes mellitus. Tentative evidence suggests that sildenafil may help men who experience antidepressant -induced erectile dysfunction.

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Viagra is a well-known treatment for erectile dysfunction, but many other approaches can help achieve and maintain erections. They include medical devices, supplements, and lifestyle changes. Research indicates that erectile dysfunction ED affects over 30—50 million men in the United States each year. Although the prevalence of this issue increases with age, it does not only affect older adults. A range of treatments and strategies can improve or reverse ED.

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