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Piperazine is effective against round worms and threadworms. Its mode of action is to inhibit neuromuscular transmission in the worm. It does this by acting on GABA receptors, which causes the opening of chloride channels and hyperpolarization of muscle cells in the worm. This causes paralysis of the worm. Piperazine has few side effects, mainly gastrointestinal disturbances.

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