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Merck is a global research-driven pharmaceutical company that, throughout its history, has devoted considerable effort to bringing its medicines, vaccines, expertise and experience to people in need around the world. Merck believes that responding to global health challenges is a strategic and humanitarian necessity and that, through public—private partnerships, significant progress can be achieved. This year-old effort has achieved a number of notable results, including positive health impacts, economic benefits, strengthened health systems, and the empowerment of communities where the delivery and administration of Mectizan are managed. The MDP serves as a model for similar health programmes in the developing world and has also laid the foundation for the current integration efforts around 'neglected' tropical diseases. It has also taught the world many valuable lessons — about how to mobilize resources to address significant health challenges — and has demonstrated that it is possible, through public—private partnerships, to deliver healthcare to long-neglected populations, despite seemingly insurmountable obstacles including inadequate financial and human resources, lack of social, economic and health infrastructures, civil unrest and political strife, and competing, high-priority health issues. Cited by lists all citing articles based on Crossref citations. Articles with the Crossref icon will open in a new tab. Search in: This Journal Anywhere. The Mectizan Donation Program: 20 years of successful collaboration — a retrospective.

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No significant difference was observed in the occurrence of negative RT-PCR tests between the groups hazard ratio, 0. Novel therapeutic agents approved for COVID have demonstrated efficacy, especially for early disease 2 ; however, they pose a huge economic burden on overstretched healthcare systems 3. Drug repurposing, an efficient strategy for identifying rapid treatment solutions by reducing developmental costs owing to preexisting data, could increase drug affordability and ensure equitable and wider drug distribution 3. However, at routine doses, ivermectin could mectizan online demonstrate additional immunomodulatory effects in vivo through its metabolites, potentially concentrated in the lung tissue 8 — Several real-world observational studies of ivermectin in COVID have been conducted, but they have demonstrated conflicting efficacy results 11 — 14, raising a worldwide debate. Of the randomized controlled trials RCTs that demonstrated favorable efficacy, some were fraudulent or of poor quality with a high bias risk 15,

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Publications des scientifiques de l'IRD. The impact of Mectizan on the transmission of onchocerciasis. In: Mectizan and onchocerciasis: a decade of accomplishment and prospects for the future: the evolution of a drug into a development concept. Annals of Tropical Medicine and Parasitology, 92 Suppl. Mectizan and onchocerciasis: a decade of mectizan online and prospects for the future: the evolution of a drug into a development concept. Annals of Tropical Medicine and Parasitology, 92 Suppl.

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