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A history of heart attackstrokeor blood clotheart diseasecongestive heart failurehigh blood pressurea history of stomach ulcers or bleedingliver or kidney diseaseasthmapolyps in your nosea bleeding or blood clotting disorderor if you smoke. Higher systemic exposure of piroxicam has been noted in subjects with CYP2C9 polymorphisms compared to normal metabolizer type subjectssee Pharmacogenomics.

Low amounts of piroxicam in milk and failure to detect piroxicam or its metabolites in the urine of 2 older infants indicates that it would not be expected to cause adverse effects in older breastfed infants. The time of the peak milk levels were 12 and 4 hours after the dose, respectively, in the 2 women. A nursing infant would receive an estimated average 3. No piroxicam could be detected in the serum of a month-old infant whose mother had been taking 20 mg daily of piroxicam for 4 months. No adverse effects were found in the breastfed infant of a patient receiving 20 mg of piroxicam daily for 4 months starting the 9th month postpartum. Acetaminophen, Flurbiprofen, Ibuprofen, Indomethacin, Naproxen. Department of Health and Human Services.

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