Nausea and vomiting are common complications of multiple conditions, procedures, and therapies, and adversely affect quality of life in millions of patients each year. Pregnancy-induced nausea alone has been estimated to cause 8. Treatment of nausea and vomiting ideally involves correcting the underlying cause. When the exact cause is not known or cannot be corrected, symptoms still can be treated. The neurotransmitters histamine, acetylcholine, serotonin, and dopamine frequently are implicated in these pathways and are the targets of most therapeutic modalities. Table 1 lists the primary classes of antiemetics, as well as specific agents in each class. Table 2 lists major adverse effects associated with each class.

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This medication is used alone or with other medications to prevent nausea and vomiting caused by cancer drug treatment chemotherapy and radiation therapy. It is also used to prevent and treat nausea and vomiting after surgery. To prevent nausea from chemotherapy, take this medication by mouth usually within 30 minutes before treatment begins. To prevent nausea from radiation treatment, take this medication by mouth 1 to 2 hours before the start of your treatment. To prevent nausea after surgery, take ondansetron by mouth 1 hour before the start of surgery.

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Common side effects include diarrhea, constipation, headache, sleepiness, and itchiness. Ondansetron was patented in and approved for medical use in The 5-HT 3 cost zofran antagonists are the primary medications used to treat and prevent chemotherapy-induced nausea and vomiting and radiotherapy-induced nausea and vomiting. A number of medications including ondansetron appear to be effective in controlling postoperative nausea and vomiting. It is more effective than metoclopramide, and less sedating than cyclizine or droperidol.

Background Limited data are available on the efficacy of ondansetron hydrochloride compared with prochlorperazine maleate for the treatment of postoperative nausea and vomiting PONV. Objective To evaluate the comparative efficacy of ondansetron and prochlorperazine for the prophylaxis of PONV in patients undergoing total hip replacement or total knee replacement procedures. Methods A randomized, double-blind, comparative trial was conducted at a tertiary care, university hospital. Rescue therapy was administered every 4 hours as needed during the initial 48 hours. Primary outcome measures were the incidences and severity of PONV.

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But I was way off in the weight loss and nausea department because I was lucky enough to be diagnosed with breast cancer in, 20 years after the introduction of the highly effective anti-nausea drug Zofran. Before the introduction of this and other powerful antiemetics, going through chemo was incredibly rough. My little Zofran pills — and other drugs like steroids and Ativan that amplify the anti-nausea effect — made it possible for me to get through chemo and radiation without throwing up once. I realize nausea and vomiting is a weird thing to uh bring up. I was certainly clueless about this; ditto for many others who told me they feared the worst, thanks to Hollywood.

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