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There has been much debate as to whether reboxetine is more efficacious than placebo in the treatment of depression. The British MHRA said in September that the study had several limitations, and that Overall the balance of benefits and risks for reboxetine remains positive in its authorised indication. In a randomised double-blind placebo-controlled trial reboxetine significantly improved the symptoms of panic disorder. A case series and open-label pilot study have demonstrated the efficacy of reboxetine in treating bulimia nervosa. Reboxetine is contraindicated in narrow-angle glaucoma, cardiovascular disease, epilepsy, bipolar disorder, urinary retention, prostatic hypertrophy, patients concomitantly on MAOIs and those hypersensitive to reboxetine or any of its excipients. Reboxetine is considered a relatively low-risk antidepressant in overdose.

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