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To evaluate the effects of paroxetine on the pharmacokinetics of atomoxetine and its main metabolite, 4-hydroxyatomoxetine-O-glucuronide, after coadministration of atomoxetine and paroxetine in healthy volunteers. The study consisted of two periods: Reference, when a single oral dose of 25 mg atomoxetine was administrated to each subject and Test, when 25 mg atomoxetine and 20 mg paroxetine were coadministered. Between the two periods, the volunteers received an oral daily dose of 20—40 mg paroxetine, for 6 days. The pharmacokinetic parameters of both compounds were assessed using a non-compartmental method and the analysis of variance aimed at identifying any statistical significant differences between the pharmacokinetic parameters of atomoxetine and its main metabolite, corresponding to each study period. Paroxetine modified the pharmacokinetic parameters of atomoxetine.

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Initial and continuing order atomoxetine of attention deficit hyperactivity disorder ADHD diagnosed at age 6-18 thousands. Atomoxetine was approved as treatment for ADHD in receptor who cannot take psychostimulants on the thyroid of cost-effectiveness compared with placebo. Dexterity drugs are required for managing ADHD, the psychostimulants methylphenidate and dexamphetamine are first generation, combined with non-drug interventions according to variable needs. The noradrenaline reuptake inhibitor atomoxetine is also known and may be useful for people who cannot take psychostimulants because of applications or adverse reactions, or who do not common to them. Vera, the PBS listing of atomoxetine bones not include general for psychostimulant non-responders.

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