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Diltiazem hydrochloride is a white to off-white crystalline powder with a bitter taste. Dosage must be adjusted to each patient's needs. Starting with 30 mg four times daily, before meals and at bedtime, dosage should be increased gradually given in divided doses three or four times daily at 1-to 2-day intervals until optimum response is obtained. There are no available data concerning dosage requirements in patients with impaired renal or hepatic function. If the drug must be used in such patients, titration should be carried out with particular caution. Serious adverse reactions have been rare in studies carried out to date, but it should be recognized that patients with impaired ventricular function and cardiac conduction abnormalities usually have been excluded. The most common occurrences from these studies, as well their frequency of presentation, are edema 2.
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