To determine whether 10 mg, 25 mg, or 50 mg metoclopramide combined with 8 mg dexamethasone, given intraoperatively, is more effective in preventing postoperative nausea and vomiting than 8 mg dexamethasone alone, and to assess benefit in relation to adverse drug reactions. Postoperative nausea and vomiting within 24 hours of surgery primary end point ; occurrence of adverse reactions. The most frequent adverse drug reactions were hypotension and tachycardia, with cumulative incidences of 8. The addition of 50 mg metoclopramide to 8 mg dexamethasone given intraoperatively is an effective, safe, and cheap way to prevent postoperative nausea and vomiting. A reduced dose of 25 mg metoclopramide intraoperatively, with additional postoperative prophylaxis in high risk patients, may be equally effective and cause fewer adverse drug reactions.

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Metoclopramide increases muscle contractions in the upper digestive tract. Metoclopramide oral is also used to treat gastroparesis slow stomach emptying in people with diabetes, which can cause heartburn and stomach discomfort after meals. You also should not use this medicine if you've had stomach or intestinal problems a blockage, bleeding, or a hole or tear, epilepsy or other seizure disorder, or an adrenal gland tumor pheochromocytoma. High doses or long-term use can cause a serious movement disorder that may not be reversible. The longer you use metoclopramide, the more likely you are to develop this movement disorder. The risk of this side effect is higher in diabetics and older adults especially women.

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