Indicated in combination with peginterferon alfa-2a for treatment of chronic hepatitis C in patients with compensated liver disease and no prior history of interferon therapy. Patients who initiate treatment prior to their 18th birthday should maintain pediatric dosing through completion of therapy. Length of treatment determined by genotype; genotypes 2 or 3 administer for 24 weeks, for genotype 1 is 48 weeks. Suspend ribavirin and alfa interferon combination therapy in patients with signs and symptoms of pancreatitis and discontinue in patients with confirmed pancreatitis. Therapy is contraindicated for use in pregnant women and in men whose female partners are pregnant; obtain negative pregnancy test before initiating therapy; patients should have periodic pregnancy tests during treatment and during the 6-month period after treatment has been stopped.

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COPEGUS ribavirin monotherapy is not effective for the treatment of chronic hepatitis C virus infection and should not be used alone for this indication. In addition, ribavirin has a multiple dose half-life of 12 days, and it may persist in non-plasma compartments for as long as 6 months. Therefore, ribavirin, including COPEGUS, is contraindicated in women who are pregnant and in the male partners of women who are pregnant. Extreme care must be taken to avoid pregnancy during therapy and for 6 months after completion of therapy in both female patients and in female partners of male patients who are taking ribavirin therapy. Patients who initiate treatment prior to their 18 th birthday should maintain pediatric dosing through the completion of therapy.

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It is used to treat chronic hepatitis C HCV viral infection. Ribavirin is a purine nucleoside analogue has broad-spectrum antiviral activity against influenza A and B, respiratory syncytial virus and many other DNA and double stranded RNA viruses. It is not recommended for children and adolescents below 18 years of age. The common side effects are headache, muscle pain, weakness, fatigue and fever. Ribavirin works by inhibiting the multiplication of many types of viruses, including the hepatitis C viruses.

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Roche's ribavirin Copegus available in all EU Countries within months. Right now there is one FDA approved ribavirin available in your pharmacy. FDa approval for the combination of Pegasys with ribavirin is expected in december. So Roche is manufacturing its own ribavirin which they have been using in their clinical studies. This ribavirin is expected to be on the market and available in your pharmacy. This is an announcement from Roche.

Aerosolized ribavirin therapy requires an experienced clinician. If worsening of respiratory function occurs, aerosolized ribavirin should be withdrawn. Aerosolized ribavirin is not for use in adults. Oral ribavirin should be used with caution in patients with anemia. The major clinical toxicity of zyrtec cheapest is hemolytic anemia.

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This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Do not pass it on to others. It may harm them, even if their signs of illness are the same as yours. This includes any possible side effects not listed in this leaflet. If you are receiving HAART, the addition of Copegus to peginterferon alfa-2a or interferon alfa-2a may increase your risk of lactic acidosis or liver failure.

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You should not use ribavirin if you have autoimmune hepatitis, severe kidney disease, or a copegus 200 mg tablet blood cell disorder. Ribavirin is not effective when used alone. It must be used together with an interferon alfa product. You should not take ribavirin with didanosine. Ribavirin can cause birth defects or death in an unborn baby.

Other less serious adverse effects have been observed with ribavirin, including fatigue, nausea, rash, and itching. In addition, ribavirin can cause severe anemia and dose adjustement is required in some patients who develop anemia. Adverse Effects Two potentially serious ribavivirn-associated adverse effects are listed as black box warnings. Ribavirin Copegus is approved for use withpeginterferon alfa-2a Pegasys for the treatment of chronic hepatitis C with compensated liver disease. Clinical Use The specific dose and duration of ribavirin therapy depends on the hepatitis C genotype, the patient's prior treatment experience, degree of liver fibrosis, and the concomitant medications used for hepatitis C therapy.

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