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Therefore, inadvertent exposure to donepezil during pregnancy should not be a reason for pregnancy termination. The effects of this exposure on a nursing infant are unknown. This does not constitute as clinical or professional advice. Morning dosing may minimize insomnia and vivid dreams. Precautions Contraindications: Known hypersensitivity to a specific drug or its derivatives is the only true contraindication.

In this study, we investigated the i role of donepezil in amyloid precursor protein APP processing and ii involvement of sorting nexin protein 33 SNX33, a member of the sorting nexin protein family, in this processing. This decrease was not affected by concomitant treatment with acetylcholine receptor antagonists. SNX33 knockdown by target-specific morpholino oligos inhibited the effects of donepezil. Many aspects of the regulatory mechanism governing APP endocytosis are still unclear.

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The usual starting dose of donepezil is 5mg one tablet or one 5ml spoonful of liquid, taken once a day. After a month, the doctor may increase your dose to 10mg one 10mg tablet or two, 5ml spoonfuls of liquid, taken once a day. It's best to take your donepezil at bedtime. This is because you may feel dizzy after you take it.

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