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Etodolac blocks the enzyme that makes prostaglandins cyclooxygenase. Etodolac is used to treat pain or inflammation caused by arthritis. Learn about side effects, interactions and indications. Pharmacology, adverse reactions, warnings and side effects. Edac EX uses:Carefully consider the potential benefits and risks of etodolac capsules and other treatment options before deciding to use etodolac capsules.

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Etodolac is contraindicated in patients with a history of etodolac 800 mg active GI disease including peptic ulcer disease, ulcerative colitis, GI perforation or GI bleeding. It is recommended not to initiate therapy with maximum doses in these patients due to the likely increase frequency of adverse reactions. Patients with a prior history of peptic ulcer disease or GI bleeding who use NSAIDs have a greater than fold increased risk for developing a GI bleed compared to patients with neither of these risk factors. Other patients at increased risk for NSAID-induced GI bleeding include elderly patients, those receiving concurrent myelosuppressive chemotherapy, corticosteroid therapy, or anticoagulant therapy, tobacco smoking patients, and patients with alcoholism.

Nonsteroidal anti-inflammatory drugs including etodolac may rarely increase the risk for a heart attack or stroke. This drug may rarely cause serious rarely fatal bleeding from the stomach or intestines. This effect can occur without warning at any time while taking this drug. See also Precautions and Drug Interactions sections.

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