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Levodopa is given orally and in order to maximize the amount that actually reaches the brain, it is given in combination with a decarboxylase inhibitor, carbidopa, which does not enter the brain. Because the drug is not converted into dopamine outside of the brain, this greatly increases the effective dose of levodopa and reduces peripheral side effects. This combination seems to be the best treatment for most Parkinsons patients, at least in the early stages. The site of decarboxylation of levodopa in patients with Parkinsons disease is uncertain, but it may be that there is sufficient enzyme in the remaining dopamine nerve terminals or that conversion takes place in other neurons as they also contain decarboxylase enzymes. Release of dopamine replaced in this way must be very abnormal but most patients seem to benefit.

Side effects are rare but dry powder inhalation may provoke bronchospasm. This can be prevented by concurrent use of a bronchodilator. Leukotriene receptor antagonists are a relatively new class of drugs that directly bind to leukotriene receptors in the lung preventing the inflammatory actions of leukotrienes particularly in the late phase of asthma.
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