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The NDA seeks indications for ARCOXIA for the treatment of osteoarthritis, rheumatoid arthritis, chronic low back pain, acute pain, dysmenorrhea, acute gouty arthritis and ankylosing spondylitis. VIOXX is Merck's once-daily medicine approved for the treatment of osteoarthritis, adult rheumatoid arthritis, management of acute pain in adults and primary dysmenorrhea. People with allergic reactions, such as asthma, to aspirin or other arthritis medicines should not take VIOXX. In rare cases, serious stomach problems, such as bleeding, can occur without warning. VIOXX cannot take the place of aspirin for the prevention of heart attack or stroke. VIOXX should not be used by women in late pregnancy. These statements involve risks and uncertainties, which may cause results to differ materially from those set forth in the statements.

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