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State of the Art of Therapeutic Endocrinology. Glucocorticoids were first introduced in the s and have become a widely prescribed class of drugs. Corticosteroids are a class of chemicals that includes steroid hormones naturally produced in the adrenal cortex of vertebrates and analogues of these hormones that are synthesized in laboratories. Corticosteroids are involved in a wide range of physiologic processes, including stress response, immune response, and regulation of inflammation, carbohydrate metabolism, protein catabolism, blood electrolyte levels, and behavior. They are some of the most common drugs for management of patients undergoing stressful situations such as surgery and dentstry Gibson It has thus become common for standard textbooks in dentistry to recommend the administration of oral or intravenous steroids in the management of oral lesions. Steroids have different effects on different tissues, which are dose dependent. The reason for varied effect of steroids lies in its mechanism of action Grover Glucocorticoids decrease the production of cytokines,chemokines, and eicosanoids and enhances the production of macrophage migration inhibitory factor Gibson Corticosteroid drugs are widely used in oral medicine such as in vesiculobullous diseases, orofacial granulomatosis, temporal arteritis and other oral mucosal disorders.

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Furthermore, the most appropriate corticosteroid and dose in the treatment of COVID have remained uncertain. We conducted a study to assess the effectiveness of methylprednisolone treatment versus dexamethasone for hospitalized COVID patients. Data were assessed based on a 9-point WHO ordinal scale extending from uninfected point 0 to death point 8. There were no significant differences between the groups on admission. However, the intervention group demonstrated significantly better clinical status compared to the control group at day 5 4. There was also a significant difference in the overall mean score between the intervention group and the control group, 3.

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