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Serious side effects include a small increased risk of uterine cancer, stroke, vision problems, and pulmonary embolism. Tamoxifen was initially made in, by chemist Dora Richardson. In, the large STAR clinical study concluded that raloxifene is also effective in reducing the incidence of breast cancer. Some cases of lower-limb lymphedema have been associated with the use of tamoxifen, due to the blood clots and deep vein thrombosis DVT that can be caused by this medication.

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The structure of tamoxifen is based on the same nucleus as diethylstilbestrol, but tamoxifen's additional side chain trans isomer imparts antiestrogenic activity. Tamoxifen is used as the primary hormonal therapy for metastatic estrogen receptor ER -positive breast cancer in both men and postmenopausal women. Adjuvant tamoxifen therapy significantly reduces the risk of breast cancer recurrence and death in women of all age groups. The benefit is greater when tamoxifen is given for 5 years rather than 1—3 years, and when the drug is given to women with ER-positive tumors.

Cytotam Tamoxifen Citrate is widely used to treat breast cancer and may be used after the patient has undergone surgery or radiation therapy. Other indications include being used for breast cancer prevention in women who are considered to be at risk and treating infertility occurring as a result of ovulation problems. Uses Cytotam Tamoxifen Citrate is widely used to treat breast cancer and may be used after the patient has undergone surgery or radiation therapy.

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