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Result: We included five RCTs, comprising a total of 1, patients, and one observational study, comprising 10, patients. Type 2 diabetes mellitus was the fourth leading cause of death and disability worldwide in, and has rapidly risen in rank since Roth et al. Approximately 1 in 11 adults worldwide had type 2 diabetes, and those affected can experience life-threatening complications, including cardiovascular and renal diseases Zheng et al. Lifestyle intervention and careful pharmacotherapeutic management are critical measures for people living with type 2 diabetes Amod, ; McGuire et al. However, the clinical relevance of such a deficiency remains unclear Zhang et al.

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