Mortality from cryptococcal meningitis remains very high in Africa. The effectiveness of FLU was derived from cohorts of consecutively enrolled patients, managed in respects other than drug therapy, as were participants in ACTA. A probabilistic sensitivity analysis assessed uncertainties and a bivariate deterministic sensitivity analysis examined the impact of varying mortality and 5FC drug costs on the ICER. The week mortality rate was The addition of 5FC to FLU is cost-effective for cryptococcal meningitis treatment in Africa and, if made available widely, could substantially reduce mortality rates among human immunodeficiency virus—infected persons in Africa. Mortality from cryptococcal meningitis CM remains unacceptably high in sub-Saharan Africa 1. The aim was to improve upon the efficacy of FLU monotherapy with regimens that could be sustained in resource-limited settings.

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A white or almost white, hygroscopic, crystalline powder. Slightly soluble in water freely soluble in methyl alcohol soluble in acetone. A white or almost white, crystalline powder. Other adverse effects include headache, dizziness, leucopenia, thrombocyto-penia, hyperlipidaemias, and raised liver enzyme values. Skin reactions are rare but exfoliative cutaneous reactions such as toxic epidermal necrolysis and Stevens-Johnson syndrome have occurred, more commonly in patients with AIDS. Hepatic necrosis has been seen rarely post mortem in patients with severe underlying disease who had received fluconazole. In one such patient, hepatotoxicity was concluded to be dose-dependent.

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