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On entering the body, drugs are treated as if they are toxic substances, which need to be detoxified, if a mechanism exists, and eliminated as soon as possible. This means that most drugs are subjected to some kind of metabolism and then excreted. Metabolism involves changes to the molecular structure of a substance and these changes are produced by the action of enzymes. This has two important effects on drug molecules: kidneys; This is not always the case. A drug metabolite may have a new and completely different pharmacological activity, or it may be as active as or more active than the original drug.

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