Fenfluramine, sold under the brand name Fintepla, is a serotonergic medication used for the treatment of seizures associated with Dravet syndrome and Lennox—Gastaut syndrome. Side effects of fenfluramine in people treated for seizures include decreased appetite, somnolence, sedation, lethargy, diarrhea, constipation, abnormal echocardiogram, fatigue, malaise, asthenia, ataxia, balance disorder, gait disturbance, increased blood pressure, drooling, excessive salivation, fever, upper respiratory tract infection, vomiting, appetite loss, weight loss, falls, and status epilepticus. Fenfluramine is indicated for the treatment of seizures associated with Dravet syndrome and Lennox—Gastaut syndrome in people age two and older. The most common adverse reactions in people with seizures include decreased appetite; drowsiness, sedation and lethargy; diarrhea; constipation; abnormal echocardiogram; fatigue or lack of energy; ataxia lack of coordination, balance disorder, gait disturbance trouble with walking ; increased blood pressure; drooling, salivary hypersecretion saliva overproduction ; pyrexia fever ; upper respiratory tract infection; vomiting; decreased weight; risk of falls; and status epilepticus. The distinctive valvular abnormality seen with fenfluramine is a thickening of the leaflet and chordae tendineae. One mechanism used to explain this phenomenon involves heart valve serotonin receptors, which are thought to help regulate growth. Since fenfluramine and its active metabolite norfenfluramine stimulate serotonin receptors, this may have led to the valvular abnormalities found in patients using fenfluramine.

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It works by decreasing appetite. It usually is taken as a single daily dose in the morning or three times a day 30 minutes before meals. Do not take a larger dose, take it more often, or take it for a longer period than your doctor tells you to. If you are taking the extended-release long-acting tablets, do not split, chew, or crush them tablet. There are some tablets that can be crushed and mixed with food. This medication may be prescribed for other uses. Take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Ask your pharmacist for a list of the ingredients. Also tell your doctor if you are taking monoamine oxidase MAO inhibitors such as isocarboxazid Marplan, phenelzine Nardil, selegiline Eldepryl, Emsam, Zelapar and tranylcypromine Parnate, or if you have stopped taking one of these medications in the past 2 weeks.

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Phenylpropanolamine PPA is a sympathomimetic agent which is used as a decongestant and appetite suppressant. In veterinary medicine, it is used to control urinary incontinence in dogs. There are four optical isomers of PPA: dextro- and levo-norephedrine, and dextro- and levo-norpseudoephedrine. Exogenous compounds in this family are degraded too rapidly by monoamine oxidase to be active at all but the highest doses. In Canada, it was withdrawn from the market on 31 May PPA acts primarily as a selective norepinephrine releasing agent.

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