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An inexpensive weight-loss drug approved 60 years ago for only short-term use also may be safe and effective for longer-term treatment, according to a study conducted by researchers at Wake Forest Baptist Health and the Patient Outcomes Research to Advance Learning PORTAL network. Most new weight-loss drugs are approved for long-term use, but unfortunately the newer drugs can be expensive if they are not covered by insurance. The researchers compared weight loss and changes in blood pressure for up to two years, and the risk of heart attack, stroke or death for up to three years, according to a patient's duration of medication use. But for those with low cardiac risk, normal blood pressure or high blood pressure that is well treated, it could be a good and affordable option, she said. The study did not examine the most effective dose of the drug or potential side effects such as anxiety or insomnia.

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